The unfolded protein response machinery in glioblastoma genesis, chemoresistance and as a druggable target.

Lucette Z SimbilyaboLiting YangJie Wen Zhixiong Liu

Published in: CNS neuroscience & therapeutics (2024)

Recent research has established the role of the UPR in GB pathophysiology and chemoresistance. Targeting its different sensors have shown promising in overcoming GB chomo- and radioresistance and inducing apoptosis.

Keyphrases

endoplasmic reticulum stress
cancer stem cells
oxidative stress
cell cycle arrest
cell death
cancer therapy
protein protein
low cost
dna damage response
amino acid
binding protein
dna damage
pi k akt