Identifying Sensitive Measures of Cognitive Decline at Different Clinical Stages of Alzheimer's Disease.
Roos J JuttenSietske A M SikkesRebecca E AmariglioRachel F BuckleyMichael J ProperziGad A MarshallDorene M RentzKeith A JohnsonCharlotte E TeunissenBart N M Van BerckelWiesje M Van der FlierPhilip ScheltensReisa A SperlingKathryn V Pappnull nullnull nullPublished in: Journal of the International Neuropsychological Society : JINS (2020)
We demonstrated that commonly used neuropsychological tests differ in their ability to capture decline depending on clinical stage within the AD continuum (preclinical to dementia). This implies that stage-specific cognitive endpoints are needed to accurately assess disease progression and increase the chance of successful treatment evaluation in AD.