Mitochondrial involvement in memory impairment induced by scopolamine in rats.

Maylin Wong-GuerraJavier Jiménez-MartinGilberto L Pardo-AndreuLuis A Fonseca-FonsecaDiogo O SouzaAdriano M de AssisJeney Ramirez-SanchezRoberto Menéndez-Soto Del ValleYanier Nuñez-Figueredo

Published in: Neurological research (2017)

In conclusion, the present results indicate that SCO induced cognitive dysfunction and oxidative stress may involve brain mitochondrial impairment, an important target for new neuroprotective compounds against AD and other dementias.

Keyphrases

oxidative stress
diabetic rats
dna damage
cerebral ischemia
ischemia reperfusion injury
high glucose
induced apoptosis
working memory
white matter
resting state
drug induced
multiple sclerosis
endothelial cells
functional connectivity
heat shock
endoplasmic reticulum stress