Sex-Specific Metabolic Pathways Were Associated with Alzheimer's Disease (AD) Endophenotypes in the European Medical Information Framework for AD Multimodal Biomarker Discovery Cohort.
Jin XuRebecca GreenMin KimJodie LordAmera EbshianaSarah WestwoodAlison L BairdAlejo J Nevado-HolgadoLiu ShiAbdul HyeStuart G SnowdenIsabelle BosStephanie J B VosRik VandenbergheCharlotte E TeunissenMara Ten KatePhilip ScheltensSilvy GabelKaren MeersmansOlivier BlinJill RichardsonEllen Elisa De RoeckSebastiaan EngelborghsKristel SleegersRegis BordetLorena RamiPetronella KettunenMagda TsolakiFrans R J VerheyDaniel AlcoleaAlberto LleóGwendoline PeyratoutMikel TaintaPeter JohannsenYvonne Freund-LeviLutz FroelichValerija DobricicGiovanni B FrisoniJosé Luis MolinuevoAnders WallinJulius PoppPablo Martinez-LageLars BertramKaj BlennowHenrik ZetterbergJohannes StrefferPieter Jelle VisserSimon LovestonePetroula ProitsiCristina Legido-Quigleynull On Behalf Of The European Medical Information Framework ConsortiumPublished in: Biomedicines (2021)
metabolic sex-specific differences were reported, covering neurotransmission and inflammation pathways with AD endophenotypes. Two metabolites, in pathways related to dopamine and serotonin, were associated to females, paving the way to personalised treatment.