Aging biomarkers: Potential mediators of association between long-term ozone exposure and risk of atherosclerosis.

Ruiying LiGongbo ChenXiaotian LiuMingming PanNing KangXiaoyu HouWei LiaoXiaokang DongYinghao YuchiZhenxing MaoWenqian HuoXian WangYuming GuoShanshan LiJian HouChongjian Wang

Published in: Journal of internal medicine (2022)

Long-term exposure to ambient ozone was associated with increased 10-year ASCVD risk, and the association was partially mediated by aging biomarkers (shortened TL and decreased mtDNA-CN). This study indicated that ambient ozone pollution-related ASCVD risk might be partially explained by the telomere-mitochondrial axis of aging.

Keyphrases

particulate matter
air pollution
hydrogen peroxide
cardiovascular disease
risk assessment
human health
type diabetes
squamous cell carcinoma
copy number
dna methylation
nitric oxide
lymph node metastasis
climate change