Influence of acquired obesity on coronary vessel wall late gadolinium enhancement in discordant monozygote twins.
Marcus R MakowskiChristian H P JansenUllrich EbersbergerTobias SchaeffterReza RazaviMassimo ManginoTim D SpectorRene M BotnarGerald F GreilPublished in: European radiology (2016)
• BMI-discordant twins allow the investigation of the influence of lifestyle factors independent from genetic confounders. • Only thirteen obesity-discordant twins were identified underlining the strong genetic component of BMI. • In female twins, a BMI increase is associated with increased coronary late gadolinium enhancement. • Increased late gadolinium enhancement in the coronary vessel wall potentially reflects increased atherosclerosis.
Keyphrases
- weight gain
- coronary artery
- coronary artery disease
- weight loss
- metabolic syndrome
- body mass index
- gestational age
- insulin resistance
- type diabetes
- cardiovascular disease
- genome wide
- high fat diet induced
- contrast enhanced
- copy number
- computed tomography
- magnetic resonance
- heart failure
- preterm birth
- adipose tissue
- skeletal muscle
- atrial fibrillation
- left ventricular