High-throughput sequencing of CD4+ T cell repertoire reveals disease-specific signatures in IgG4-related disease.

Liwen WangPanpan ZhangJieqiong LiHui LuLinyi PengJing LingXuan ZhangXiaofeng ZengYan ZhaoWen Zhang

Published in: Arthritis research & therapy (2019)

According to our study of CD4+ T cells from eight IgG4-RD patients, TCR repertoires of IgG4-RD patients were different from that of healthy controls in the proportion of expanded and coding degenerated clones and CDR3 length distribution. In addition, IgG4-RD-specific TCR sequences and clusters were identified in our study.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
high throughput sequencing
genome wide
patient reported