Identification of antibody targets associated with lower HIV viral load and viremic control.
Wendy Grant-McAuleyWilliam R MorgenlanderIngo RuczinskiKai KammersOliver LaeyendeckerSarah E HudelsonManjusha ThakarEstelle Piwowar-ManningWilliam ClarkeAutumn BreaudHelen AylesPeter BockAyana MooreBarry KosloffKwame ShanaubeSue-Ann MeehanAnneen van DeventerSarah FidlerRichard HayesH Benjamin LarmanSusan H Eshlemannull nullPublished in: PloS one (2024)
We identified HIV antibody targets associated with lower VL and HIV controller status 1-2 years after infection. Robust aggregate responses to these targets and broad antibody reactivity across the HIV genome were also associated with lower VL and controller status. These findings provide novel insights into the relationship between humoral immunity and viral containment that could help inform the design of antibody-based approaches for reducing HIV VL.