Quanzhen Yiqi decoction attenuates inflammation in mice with smoking-induced COPD by activating the Nrf2/HO-1 pathway and inhibiting the NLRP3 inflammasome.
Jiamin ZengZhenqiu LiWanyan LiZhu LiangYuewen LuoCaiping LiSida LiaoKexin WangYuanlong HuYuanyuan LiQiuling LiangWenju LuLu LiZhijuan WuDapeng ZhangZhimin ZhangPublished in: The Journal of pharmacy and pharmacology (2024)
Our study suggested that QZYQ can improve the function and histology of the lungs and reduce inflammatory cell recruitment. QZYQ inhibits ROS production and NLRP3 inflammasome activation by upregulating Nrf2 to reduce lung injury. The anti-inflammatory effects of QZYQ are similar to those of DEX.
Keyphrases
- nlrp inflammasome
- oxidative stress
- diabetic rats
- anti inflammatory
- signaling pathway
- dna damage
- chronic obstructive pulmonary disease
- single cell
- high glucose
- lung function
- smoking cessation
- stem cells
- drug induced
- type diabetes
- pi k akt
- endothelial cells
- high fat diet induced
- bone marrow
- cell proliferation
- insulin resistance
- mesenchymal stem cells
- air pollution