11β hydroxysteroid dehydrogenase 1: a new marker for predicting response to immune-checkpoint blockade therapy in non-small-cell lung carcinoma.

Ryoko Saito Yasuhiro MikiTakuto AbeEisaku MiyauchiJiro AbeRen NanamiyaChihiro InoueIkuro SatoHironobu Sasano

Published in: British journal of cancer (2020)

Our study is the first report clarifying the inhibitory effects of intratumourally synthesised cortisol through 11βHSD1 on immune cell migration. We propose that the response to IC blockade therapy in NSCLC may be predicted by 11βHSD1.

Keyphrases

cell migration
cell therapy
single cell
stem cells
bone marrow