The pattern of rpoB gene mutation of Mycobacterium tuberculosis and predictors of rifampicin resistance detected by GeneXpert MTB/RIF assay in Tanzania.
Peter Richard TorokaaMtebe Venance MajigoHeledy KileoLoveness UrioMariam R MbwanaMariam C MonahSephord Saul NtibabaraJasper KimamboPaschal SelemanCollins FranklinRobert BalamaRiziki M KisongaAgricola JoachimPublished in: PloS one (2024)
The rate of RR was lower compared to other studies in Tanzania, with probe E mutations the most prevalent. Patients with disseminated TB, HIV co-infection and those with prior exposure to anti-TB had more risk of RR. The findings highlight the need to strengthen surveillance of multidrug-resistant TB among high risk patients.
Keyphrases
- mycobacterium tuberculosis
- pulmonary tuberculosis
- multidrug resistant
- end stage renal disease
- newly diagnosed
- ejection fraction
- hiv infected
- human immunodeficiency virus
- hepatitis c virus
- high throughput
- peritoneal dialysis
- hiv aids
- drug resistant
- acinetobacter baumannii
- quantum dots
- hiv testing
- pseudomonas aeruginosa
- living cells