PI3K/AKT/Nrf2 signalling pathway is involved in the ameliorative effects of xanthohumol on amyloid β-induced oxidative damage and bone loss.

Tianshuang XiaXiaoyan LiuNani WangYiping JiangHuanhuan BaiWeifan XuKunmiao FengTing HanHai-Liang Xin

Published in: The Journal of pharmacy and pharmacology (2022)

It was the first time to reveal the antioxidative and osteoprotective effect of XAN through regulating PI3K/AKT/Nrf2 pathway in Aβ-injured osteoblasts, which provides reference for the clinical application of XAN in the prevention and treatment of OP.

Keyphrases

pi k akt
bone loss
signaling pathway
cell cycle arrest
cell proliferation
oxidative stress
diabetic rats
high glucose
single cell
drug induced
gene expression