Refining epigenetic prediction of chronological and biological age.

Elena BernabeuDaniel L McCartneyDanni A GaddRobert F HillaryAke T LuLee MurphyNicola WrobelArchie CampbellSarah E HarrisDavid LiewaldCaroline HaywardCathie SudlowSimon R CoxKathryn L EvansSteve HorvathAndrew M McIntoshMatthew R RobinsonCatalina A VallejosRiccardo E Marioni

Published in: Genome medicine (2023)

The integration of multiple large datasets, EpiScores, non-linear DNAm effects, and new approaches to feature selection has facilitated improvements to the blood-based epigenetic prediction of biological and chronological age.

Keyphrases

dna methylation
gene expression
machine learning
deep learning
rna seq