Population pharmacokinetics of vancomycin in term neonates with perinatal asphyxia treated with therapeutic hypothermia.

Marlotte A A van der VeerTimo R de HaanLinda G W FrankenReinier M van HestFloris GroenendaalPeter H DijkWillem P de BoodeSinno SimonsKoen P DijkmanHenrica L M van StraatenMonique RijkenFilip CoolsDebbie H G M NuytemansAnton H van KaamYuma A BijleveldRon A A Mathôtnull null

Published in: British journal of clinical pharmacology (2024)

Results of this study suggest that vancomycin clearance is reduced in term neonates with perinatal asphyxia treated with TH. Lower dosing regimens should be considered followed by model-informed precision dosing.

Keyphrases

preterm infants
low birth weight
methicillin resistant staphylococcus aureus
pregnant women
cardiac arrest
gestational age
brain injury
newly diagnosed
staphylococcus aureus