Transcriptomics reveals transient and dynamic muscle fibrosis and atrophy differences following spinal cord injury in rats.
Hui Jean KokDrew B FletcherJacob C OsterChristine F ConoverElisabeth R BartonJoshua F YarrowPublished in: Journal of cachexia, sarcopenia and muscle (2024)
Our results substantiate many known pathologic features of SCI-induced wasting in rat skeletal muscle and identify a progressive and dynamic transcriptional landscape within the post-SCI soleus. Future studies are warranted to consider these therapeutic treatment windows when countering SCI muscle pathology.
Keyphrases
- spinal cord injury
- skeletal muscle
- spinal cord
- neuropathic pain
- single cell
- insulin resistance
- multiple sclerosis
- gene expression
- high glucose
- oxidative stress
- neoadjuvant chemotherapy
- current status
- locally advanced
- radiation therapy
- squamous cell carcinoma
- metabolic syndrome
- combination therapy
- adipose tissue
- subarachnoid hemorrhage
- replacement therapy
- heat stress
- liver fibrosis