DNA methylation analyses of the candidate genes identified by a methylome-wide association study revealed common epigenetic alterations in schizophrenia and bipolar disorder.

Hiroko SugawaraYui MurataTempei IkegameRie SawamuraShota ShimanagaYusuke TakeokaTakeo SaitoMasashi IkedaAkane YoshikawaFumichika NishimuraYoshiya KawamuraChihiro KakiuchiTsukasa SasakiNakao IwataMamoru HashimotoKiyoto Kasai Tadafumi KatoMiki BundoKazuya Iwamoto

Published in: Psychiatry and clinical neurosciences (2018)

Hypomethylation of FAM63B and IR on chromosome 16 could be common epigenetic risk factors for SZ and BD. Further comprehensive epigenetic studies for BD, such as MWAS, will uncover the extent of similarity and uniqueness of epigenetic alterations.

Keyphrases

dna methylation
bipolar disorder
gene expression
genome wide
major depressive disorder
copy number
single cell