Impaired type I interferon regulation in the blood transcriptome of recurrent asthma exacerbations.

Jose L GomezMaria P DiazGustavo NinoClemente J Britto

Published in: BMC medical genomics (2018)

Subjects with asthma and multiple AETRIs display a pro-inflammatory signature at baseline, associated with elevated STAT, IL-15 and ISGs, and an impaired STAT1 response during acute asthma exacerbations.

Keyphrases

chronic obstructive pulmonary disease
lung function
cystic fibrosis
allergic rhinitis
cell proliferation
liver failure
gene expression
dendritic cells
single cell
genome wide
rna seq
intensive care unit
air pollution
hepatitis b virus
aortic dissection