Assessment of effectiveness of anakinra and canakinumab in patients with colchicine-resistant/unresponsive familial Mediterranean fever.

Ali Şahin Mehmet Emin Derin Fatih Albayrak Burak Karakaş Yalçın Karagöz

Published in: Advances in rheumatology (London, England) (2020)

Anti-IL-1 agents are effective and safe in the treatment of FMF patients. These agents are particularly effective at reducing proteinuria in patients with GFR ≥ 60 ml/min/m2, but less effective in cases with FMF associated with arthritis and sacroiliitis. Large and long follow-up studies are now needed to establish the long-term effects of these treatments.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
systematic review
rheumatoid arthritis
prognostic factors
early onset
combination therapy
smoking cessation