Biomarkers of 4-hydroxy- N,N -methylpropyltryptamine (4-OH-MPT) intake identified from human hepatocyte incubations.

Francesco P Busardò Sara Malaca Marilyn Ann Huestis Adriano Tagliabracci Anastasio Tini Francesco Paolo Busardò

Published in: Expert opinion on drug metabolism & toxicology (2023)

-propyltryptamine (4-OH-PT) as metabolite biomarkers of 4-OH-MPT consumption after glucuronide/sulfate hydrolysis in biological samples to improve detection of 4-OH-MPT and phase I metabolites; 4-OH-MPT-glucuronide is suggested as an additional biomarker when hydrolysis is not performed. Further research on the metabolism of structural analogues is necessary to evaluate the specificity of 4-OH-MPT metabolite biomarkers.

Keyphrases

endothelial cells
ms ms
anaerobic digestion
physical activity
weight gain
liver injury
loop mediated isothermal amplification
structural basis
sensitive detection
molecular dynamics simulations