Silica-coated magnetic nanoparticles activate microglia and induce neurotoxic D-serine secretion.

Tae Hwan ShinDa Yeon LeeBalachandran ManavalanShaherin BasithYun-Cheol NaCheolho YoonHyeon-Seong LeeMan Jeong PaikGwang Lee

Published in: Particle and fibre toxicology (2021)

MNPs@SiO2(RITC)-induced activation of microglia triggers excitotoxicity in neurons via D-serine secretion, highlighting the importance of neurotoxicity mechanisms incurred by nanoparticle-induced microglial activation.

Keyphrases

magnetic nanoparticles
inflammatory response
high glucose
diabetic rats
neuropathic pain
drug induced
spinal cord
protein kinase
endothelial cells
oxidative stress
lps induced