SIRT3 alleviates painful diabetic neuropathy by mediating the FoxO3a-PINK1-Parkin signaling pathway to activate mitophagy.

Jing YangZhuoying YuYe JiangZixian ZhangYue TianJie CaiMin WeiYanhan LyuDongsheng YangShixiong ShenGuo-Gang Xing Min Li

Published in: CNS neuroscience & therapeutics (2024)

These results showed that SIRT3 overexpression ameliorates PDN via activation of FoxO3a-PINK1-Parkin-mediated mitophagy, suggesting that SIRT3 may become an encouraging therapeutic strategy for PDN.

Keyphrases

signaling pathway
pi k akt
transcription factor
oxidative stress
ischemia reperfusion injury
cell proliferation
mouse model
type diabetes
nlrp inflammasome
epithelial mesenchymal transition
wound healing