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IL-17A is a common and critical driver of impaired lung function and immunopathology induced by influenza virus, rhinovirus and respiratory syncytial virus.

Xiaoming LiuThi Hiep NguyenLeon SokulskyXiang LiKeilah G NettoAlan Chen-Yu HsuChi LiuKaren LaurieIan G BarrHock TayFiona EyersPaul S FosterMing Yang
Published in: Respirology (Carlton, Vic.) (2021)
IL-17A is a common pathogenic molecule regulating disease induced by three prevalent respiratory viruses. Targeting the IL-17A pathway may provide a unified approach to the treatment of these respiratory infections alleviating both inflammation-induced lesions and difficulties in breathing.
Keyphrases
  • lung function
  • respiratory syncytial virus
  • cystic fibrosis
  • chronic obstructive pulmonary disease
  • air pollution
  • oxidative stress
  • combination therapy
  • genetic diversity
  • replacement therapy