Nadolol Attenuates Brain Cell Ferroptosis in Ischemic Stroke Rats by Targeting the HOIL-1/IRP2 Pathway.
Xiao-Yan YangWen-Jun Zhunull Di-ChenDan PengJun PengZhi-Jun ZhouXiu-Ju LuoPublished in: CNS & neurological disorders drug targets (2024)
In terms of these findings, it is concluded that nadolol can protect the ischemic rats' brains against ferroptosis by targeting the HOIL-1/IRP2 pathway, thereby preventing intracellular iron overload. Thus, nadolol may be a novel indication for treating patients with ischemic stroke.