Two-Dimensional Nanozymes Modulate Gut Microbiota and T-Cell Differentiation for Inflammatory Bowel Disease Management.

Intestinal commensal microbiota dysbiosis and immune dysfunction are significant exacerbating factors in inflammatory bowel disease (IBD). To address these problems, we developed Pluronic F-127-coated tungsten diselenide (WSe 2 @F127) nanozymes by simple liquid-phase exfoliation. The abundant valence transitions of elemental selenium (Se 2- /Se 4+ ) and tungsten (W 4+ /W 6+ ) enable the obtained WSe 2 @F127 nanozymes to eliminate reactive oxygen/nitrogen species (RONS). In addition, the released tungsten ions were capable of inhibiting the proliferation of Escherichia coli. In a model of DSS-induced colitis, WSe 2 @F127 nanozymes modulated the gut microbiota by increasing the abundance of bacteria S24-7 and significantly reducing the abundance of Enterobacteriaceae. Moreover, WSe 2 @F127 nanozymes inhibited T-cell differentiation and improved intestinal immune barrier function in a model of Crohn's disease. The WSe 2 @F127 nanozymes effectively alleviate IBD by reducing oxidative stress damage, modulating intestinal microbial populations, and remodeling the immune barrier. This article is protected by copyright. All rights reserved.