Metabolic synthetic lethality by targeting NOP56 and mTOR in KRAS-mutant lung cancer.

Zhang YangShun-Qing LiangLiang ZhaoHaitang YangThomas M MartiBalazs HegedüsYanyun GaoBin ZhengChun ChenWenxiang WangPatrick DornGregor J KocherRalph A SchmidRen-Wang Peng

Published in: Journal of experimental & clinical cancer research : CR (2022)

Our findings reveal a previously unrecognized mechanism in which NOP56 and mTOR cooperate to play a homeostatic role in the response to oxidative stress and suggest a new rationale for the treatment of KRAS-mutant cancers.

Keyphrases

wild type
oxidative stress
cell proliferation
dna damage
clinical trial
gene expression
young adults
combination therapy
replacement therapy