Novel DNA Methylation Biomarker Panel for Detection of Esophageal Adenocarcinoma and High-Grade Dysplasia.

Ming Yu Helen R MoinovaAmber WillbanksVictoria K CannonTing WangKelly T CarterAndrew KazDeepti ReddiJohn M Inadomi E Georg Luebeck Prasad G IyerMarcia I CantoJean S WangNicholas J ShaheenPrashanti N ThotaJoseph E WillisThomas LaFramboiseAmitabh ChakSanford D MarkowitzWilliam M Grady

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

A novel DNA methylation marker panel differentiates HGD/EAC from SQ/NDBE. DNA-methylation-based molecular assays hold promise for the detection of HGD/EAC using esophageal brushing samples.

Keyphrases

dna methylation
high grade
genome wide
gene expression
loop mediated isothermal amplification
real time pcr
label free
squamous cell carcinoma
copy number
high throughput
big data
rectal cancer
sensitive detection