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Improved Graft Function following Desensitization of Anti-AT 1 R and Autoantibodies in a Heart Transplant Recipient Negative for Donor-Specific Antibodies with Antibody-Mediated Rejection: A Case Report.

Regina JungKevin LyMichiko TaniguchiAileen Grace ArriolaChristopher GravanteDerek ShinnLeena MathewEman A HamadSteven GeierAbdelhamid Liacini
Published in: International journal of molecular sciences (2024)
HLA donor-specific antibodies (DSAs) pre and post transplant increase the risk of antibody-mediated rejection (AMR) and lead to poor graft survival. Increasing data exist to support the involvement of non-HLA antibodies in triggering an immunological response. The development of non-HLA antibodies specific for AT 1 R is associated with poor clinical outcomes in orthotopic heart transplant recipients. This case presents an investigation of non-HLA antibodies in a 56-year-old female heart transplant recipient diagnosed with AMR in the absence of DSAs.
Keyphrases
  • heart failure
  • atrial fibrillation
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  • machine learning
  • deep learning