Multi-omic phenotyping reveals host-microbe responses to bariatric surgery, glycaemic control and obesity.
Nicholas Charles PenneyKai Tai Derek YeungIsabel Garcia-PerezJoram Matthias PosmaAleksandra KopytekBethany GarrattHutan AshrafianGary S FrostJulian R MarchesiSanjay PurkayasthaLesley HoylesAra DarziElaine HolmesPublished in: Communications medicine (2022)
We identify multi-omic signatures associated with responses to surgery, body mass index, and glycaemic control. Improved understanding of gut microbiota - host co-metabolism may lead to novel therapies for weight-loss or diabetes. However, further experiments are required to provide mechanistic insight into the role of the gut microbiota in host metabolism and establish proof of causality.
Keyphrases
- weight loss
- bariatric surgery
- type diabetes
- glycemic control
- roux en y gastric bypass
- obese patients
- gastric bypass
- minimally invasive
- insulin resistance
- cardiovascular disease
- weight gain
- coronary artery bypass
- genome wide
- dna methylation
- emergency department
- physical activity
- gene expression
- body mass index
- adverse drug
- single cell