Non-invasive imaging of tau-targeted probe uptake by whole brain multi-spectral optoacoustic tomography.
Patrick VagenknechtArtur LuzginMaiko OnoBin JiMakoto HiguchiDaniela NoainCinzia A MaschioJens SobekZhenyue ChenUwe KonietzkoJuan A GerezRoland RiekDaniel RazanskyJan KlohsRoger M NitschXose Luis Dean-BenRuiqing NiPublished in: European journal of nuclear medicine and molecular imaging (2022)
We demonstrated non-invasive whole-brain imaging of tau in P301L mice with vMSOT system using PBB5 at a previously unachieved ~ 115 μm spatial resolution. This platform provides a new tool to study tau spreading and clearance in a tauopathy mouse model, foreseeable in monitoring tau targeting putative therapeutics.
Keyphrases
- cerebrospinal fluid
- mouse model
- high resolution
- resting state
- white matter
- cancer therapy
- functional connectivity
- optical coherence tomography
- multiple sclerosis
- high throughput
- cerebral ischemia
- single molecule
- magnetic resonance
- quantum dots
- drug delivery
- blood brain barrier
- brain injury
- subarachnoid hemorrhage
- insulin resistance