Polygenic Risk Scores for Prediction of Subclinical Coronary Artery Disease in Persons Living with HIV: The Swiss HIV Cohort Study.
Isabella C SchoepfChristian W ThorballHelen KovariBruno LedergerberRonny R BuechelAlexandra CalmyRainer WeberPhilipp A KaufmannRené NkoulouJohannes M SchwenkeDominique L BraunJacques FellayPhilip E Tarrnull nullPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)
In Swiss PLWH, subclinical CAD is independently associated with an individual CAD-associated PRS. Combining non-genetic and genetic cardiovascular risk factors provided the most powerful subclinical CAD prediction.
Keyphrases
- coronary artery disease
- cardiovascular risk factors
- percutaneous coronary intervention
- cardiovascular events
- coronary artery bypass grafting
- genome wide
- antiretroviral therapy
- hiv positive
- cardiovascular disease
- metabolic syndrome
- hiv infected
- hepatitis c virus
- human immunodeficiency virus
- hiv testing
- copy number
- men who have sex with men
- hiv aids
- aortic stenosis
- heart failure