Using "-omics" Data to Inform Genome-wide Association Studies (GWASs) in the Osteoporosis Field.
Abdullah AboodCharles R FarberPublished in: Current osteoporosis reports (2021)
The bone field is beginning to adopt approaches that are commonplace in other disease disciplines. The slower progress has been due in part to the lack of large-scale "omics" data on bone and bone cells. This is however changing, and approaches such as eQTL colocalization, transcriptome-wide association studies (TWASs), network, and integrative approaches are beginning to provide significant insight into the genes responsible for BMD GWAS associations. The use of "-omics" data to inform BMD GWASs has increased in recent years, leading to the identification of novel regulators of BMD in humans. The ultimate goal will be to use this information to develop more effective therapies to treat and ultimately prevent osteoporosis.
Keyphrases
- bone mineral density
- single cell
- postmenopausal women
- electronic health record
- big data
- genome wide association
- genome wide
- soft tissue
- induced apoptosis
- bone loss
- rna seq
- gene expression
- healthcare
- oxidative stress
- transcription factor
- machine learning
- cell cycle arrest
- data analysis
- cell proliferation
- network analysis
- cell death
- endoplasmic reticulum stress