Association of APOE genotype and cerebrospinal fluid Aβ and tau biomarkers with cognitive and motor phenotype in amyotrophic lateral sclerosis.
Alessio MaranzanoFederico VerdeAntonella DubiniSilvia TorreEleonora ColomboAlberto DorettiFrancesco GentileArianna ManiniIlaria MiloneAlberto BrusatiSilvia PeverelliSerena SantangeloEdoardo Gioele SpinelliErminio TorresaniDavide GentiliniStefano MessinaClaudia MorelliBarbara PolettiFederica AgostaAntonia RattiMassimo FilippiVincenzo SilaniNicola TicozziPublished in: European journal of neurology (2024)
APOE haplotype and CSF Aβ biomarkers are associated with cognitive deficits in ALS and particularly with memory impairment. This might partly reflect AD-like pathophysiological processes, but additional ALS-specific mechanisms could be involved.