Interactive effect between ATPase-related genes and early-life tobacco smoke exposure on bronchial hyper-responsiveness detected in asthma-ascertained families.

Marie-Hélène DizierPatricia Margaritte-JeanninLucile PainChloé SarnowskiMyriam BrossardHamida MohamdiNolwenn LavielleMarie-Claude C BabronJocelyne JustMark LathropCatherine LapriseEmmanuelle BouzigonFlorence DemenaisRachel Nadif

Published in: Thorax (2018)

The SNPs showing interaction with ETS belong to the ATP8A1 and ABCA1 genes, which play a role in the maintenance of asymmetry and homeostasis of lung membrane lipids.

Keyphrases

early life
genome wide
chronic obstructive pulmonary disease
transcription factor
lung function
dna methylation
allergic rhinitis
bioinformatics analysis