Visualization of thermal damage using 68 Ga-FAPI-PET/CT after pulmonary vein isolation.

Jana KupusovicLukas KesslerStephan G NekollaLisa RiesingerManuel M WeberJustin FerdinandusSimon KochhäuserTienush RassafReza WakiliChristoph RischplerJohannes Siebermair

Published in: European journal of nuclear medicine and molecular imaging (2021)

We demonstrate in-vivo visualization of 68 Ga-FAPI uptake as a surrogate for fibroblast activation after PVI. CBA seems to cause more pronounced fibroblast activation following tissue injury than RFA. Future studies are warranted to assess if this modality can contribute to a better understanding of the mechanisms of AF recurrence after PVI by lesion creation and gap assessment.

Keyphrases

pet ct
positron emission tomography
atrial fibrillation
oxidative stress
current status
radiofrequency ablation
computed tomography
case control