The role of pain and psychological distress in fatigue: a co-twin and within-person analysis of confounding and causal relations.

Daniel Løke Marianne Løvstad Nada Andelic Stein Andersson Eivind Ystrøm Olav Vassend

Published in: Health psychology and behavioral medicine (2022)

The findings indicate that a significant proportion of the association between fatigue, pain and distress is due to genetic and environmental confounding. Pain and distress exert significant, albeit smaller effects on fatigue even when controlling for genetic and stable environmental contributions, indicating direct effects. Potential etiological pathways and underlying mechanisms are discussed.

Keyphrases

chronic pain
pain management
sleep quality
neuropathic pain
human health
depressive symptoms
spinal cord
dna methylation
climate change