CLIPPERS and its mimics: evaluation of new criteria for the diagnosis of CLIPPERS.
Guillaume TaiebPatricia MuleroDimitri PsimarasBob W van OostenJörg D SeebachRomain MarignierFernando PicoValérie RigauYuji UenoClaire DuflosVera FominykhVincent GuiraudChristine Lebrun-FrénayJean-Philippe CamdessanchéPhilippe KerschenGuido AhleNieves TéllezAlex RoviraKhe Hoang-XuanJean PelletierPierre Labaugenull nullPublished in: Journal of neurology, neurosurgery, and psychiatry (2019)
Our study highlights that (1) nodular enhancement should be considered more as an unusual finding than a red flag excluding the diagnosis of CLIPPERS; (2) red flags may occur up to 18 months after disease onset; (3) as opposed to CLIPPERS-mimics, no relapse occurs when the daily dose of prednisone/prednisolone is ≥ 30 mg; and (4) brain biopsy should target an atypical enhancing lesion when non-invasive investigations remain inconclusive.