Type 2 diabetes subgroups and response to glucose-lowering therapy: Results from the EDICT and Qatar studies.

Tamam Abdul-GhaniCurtiss PuckettOsama MigahidSiham AbdelganiAyman MigahedJohn AdamsCurtis TriplittMuhammad Abdul-GhaniAmin JayyousiMuhammad A Abdul-Ghani

Published in: Diabetes, obesity & metabolism (2022)

Distinct metabolic phenotypes characterize different T2DM clusters and differential responses to glucose-lowering therapies. Participants with severe insulin deficiency respond better to agents that preserve beta-cell function, while, surprisingly, patients with severe insulin resistance did not respond favourably to insulin sensitizers.

Keyphrases

type diabetes
glycemic control
blood glucose
insulin resistance
early onset
cardiovascular disease
high fat diet
polycystic ovary syndrome
adipose tissue
weight loss
metabolic syndrome
stem cells
skeletal muscle
mesenchymal stem cells
smoking cessation