c-Jun as a one-way valve at the naive to primed interface.

Dongwei LiLing LuoLin GuoChuman WuRan ZhangYuling PengMenghua WuJunqi KuangYan LiYudan ZhangJun XieWenxiu XieRui MaoGang MaXiuling FuJiekai ChenAndrew P HutchinsDuanqing Pei

Published in: Cell & bioscience (2023)

The results of this study indicate that c-Jun can function as a chromatin stabilizer in primed EpiSCs, to maintain the epigenetic cell type state and act as a one-way valve for cell fate conversions.

Keyphrases

cell fate
aortic valve
mitral valve
gene expression
aortic stenosis
dna methylation
dna damage
transcription factor
genome wide
hiv infected
transcatheter aortic valve replacement
heart failure
left ventricular
coronary artery disease
oxidative stress