Does Transfusion of Red Blood Cells Impact Germline Genetic Test Results?

Margaret A DiGuardoSarah J KesterVictor J MahaffeyScott A HammelKatelyn K HeaserChristopher D HofichCraig D TauscherSarah E KerrJennifer L OliveiraEapen K JacobAnn M Moyer

Published in: Journal of personalized medicine (2020)

donor-derived DNA from leukoreduced blood products is unlikely to interfere with the interpretation of germline genetic testing in immunocompetent recipients but may interfere in immunocompromised recipients.

Keyphrases

red blood cell
dna repair
kidney transplantation
circulating tumor
cardiac surgery
cell free
single molecule
genome wide
copy number
dna damage
sickle cell disease
dna methylation
nucleic acid
gene expression
acute respiratory distress syndrome