Seizure onset patterns predict outcome after stereo-electroencephalography-guided laser amygdalohippocampotomy.
Andrew J MichalakAdam GreenblattShasha WuSteven TobochnikHina DaveRamya RaghupathiYasar T EsengulAntonio GuerraJames X TaoNaoum P IssaGarth R CosgroveBradley LegaPeter WarnkeH Isaac ChenTimothy LucasSameer A ShethGarrett P BanksNathalie JetteNeil FeldsteinBrett E YoungermanGuy McKhannKathryn A DavisCatherine A SchevonPublished in: Epilepsia (2023)
Patients who underwent SLAH after stereo-EEG had a low probability of seizure freedom at two years, but SOPs successfully predicted seizure recurrence in a subset of patients. This study provides proof of concept that SOPs distinguish between hippocampal seizure onset and spread and supports using SOPs to improve selection of SLAH candidates.