The Vitamin D Metabolite Ratio (VMR) is a Biomarker of Vitamin D Status That is Not Affected by Acute Changes in Vitamin D Binding Protein.

Anushree DugarAndrew N HoofnagleAmber P SanchezDavid M WardJody Corey-BloomJonathan H ChengJoachim H IxCharles Ginsberg

Published in: Clinical chemistry (2023)

Changes in VDBP concentration across TPE parallel changes in 25(OH)D, 1,25(OH)2D, and 24,25(OH)2D3, suggesting that concentrations of these metabolites reflect underlying VDBP concentrations. The VMR is stable across a TPE session despite a 65% reduction in VDBP. These findings suggest that the VMR is a marker of vitamin D status independent of VDBP levels.

Keyphrases

binding protein
liver failure
ms ms
high intensity
drug induced
aortic dissection
transcranial direct current stimulation
intensive care unit
working memory
mechanical ventilation