Overexpression of HOXB4 Promotes Protection of Bone Marrow Mesenchymal Stem Cells Against Lipopolysaccharide-Induced Acute Lung Injury Partially Through the Activation of Wnt/β-Catenin Signaling.

Shan Lin Qingui ChenLishan ZhangShanhui GeYuling LuoWanmei HeCaixia XuMian Zeng

Published in: Journal of inflammation research (2021)

Coculturing of BMSCHOXB4 prevented LPS-induced EC injury by reversing the inactivation of the Wnt/β-catenin signaling pathway. An in vivo study remains warranted to ascertain whether engraftment of BMSCHOXB4 can be an attractive strategy for the treatment of ALI/ARDS.

Keyphrases

lipopolysaccharide induced
inflammatory response
lps induced
cell proliferation
stem cells
acute respiratory distress syndrome
transcription factor
extracorporeal membrane oxygenation
combination therapy