Deep-tissue real-time imaging of drug-induced liver injury with peroxynitrite-responsive 19F MRI nanoprobes.
Ao LiLingxuan LiXing LiuDongxia ChenYifan FanHongyu LinJinhao GaoPublished in: Chemical communications (Cambridge, England) (2021)
Peroxynitrite is an important biomarker for assessing drug-induced liver injury (DILI), which is critical for the development and use of drugs. Herein, we report the development of peroxynitrite-responsive self-assembled 19F MRI nanoprobes, which enable the sensitive imaging of peroxynitrite in L02 cells subjected to oxidative stress and living mice with DILI.
Keyphrases
- drug induced
- fluorescent probe
- living cells
- induced apoptosis
- oxidative stress
- high resolution
- fluorescence imaging
- magnetic resonance imaging
- contrast enhanced
- cancer therapy
- diffusion weighted imaging
- adverse drug
- dna damage
- emergency department
- computed tomography
- magnetic resonance
- type diabetes
- mass spectrometry
- signaling pathway
- photodynamic therapy
- high fat diet induced
- adipose tissue
- cell death
- heat shock
- wild type