Individual response to mTOR inhibition in delaying replicative senescence of mesenchymal stromal cells.

Eliane AntonioliNatália TorresMario FerrettiCarla de Azevedo PiccinatoAndrea Laurato Sertie

Published in: PloS one (2019)

Taken together, our results suggest that some, but not all, BM-MSC samples would benefit from using rapamycin to postpone replicative arrest and reinforce a critical role of p16INK4A protein downregulation in this process.

Keyphrases

cell proliferation
cell cycle
bone marrow
dna damage
endothelial cells
signaling pathway
protein protein
amino acid
binding protein