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Conventional and Genetic Evidence on the Association between Adiposity and CKD.

Pengfei ZhuWilliam G HerringtonRichard HaynesJonathan R EmbersonMartin J LandrayCathie L M SudlowMark WoodwardColin BaigentSarah LewingtonNatalie Staplin
Published in: Journal of the American Society of Nephrology : JASN (2020)
Genetic analyses suggest that conventional associations between central and general adiposity with CKD are largely causal. However, conventional approaches underestimate mediating roles of diabetes, BP, and their correlates. Genetic approaches suggest these mediators explain most of adiposity-CKD-associated risk.
Keyphrases
  • chronic kidney disease
  • insulin resistance
  • genome wide
  • copy number
  • type diabetes
  • weight gain
  • dna methylation
  • metabolic syndrome
  • adipose tissue
  • physical activity