Three-Component Cross-Electrophile Coupling: Regioselective Electrochemical Dialkylation of Alkenes.

The cross-electrophile dialkylation of alkenes enables the formation of two C(sp 3 )-C(sp 3 ) bonds from readily available starting materials in a single transformation, thereby providing a modular and expedient approach to building structural complexity in organic synthesis. Herein, we exploit the disparate electronic and steric properties of alkyl halides with varying degrees of substitution to accomplish their selective activation and addition to alkenes under electrochemical conditions. This method enables regioselective dialkylation of alkenes without the use of a transition-metal catalyst and provides access to a diverse range of synthetically useful compounds.