Emerging RNA-Dependent RNA Polymerase Mutation in a Remdesivir-Treated B-cell Immunodeficient Patient With Protracted Coronavirus Disease 2019.
Martin MartinotAude JarySamira Fafi-KremerValentin LeducqHéloïse M DelagreverieMarc GarnierJérôme PacanowskiArsenne MekinianFrance PirennePierre TiberghienVincent CalvezCatherine HumbrechtAnne-Geneviève MarcelinKarine LacombePublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly discovered virus for which remdesivir is the only antiviral available. We report the occurrence of a mutation in RdRP (D484Y) following treatment with remdesivir in a 76-year-old female with post-rituximab B-cell immunodeficiency and persistent SARS-CoV-2 viremia. A cure was achieved after supplementation with convalescent plasma.