β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells.
Evelina MieleAgnese PoFederica BegalliLaura AntonucciAngela MastronuzziCarlo Efisio MarrasAndrea CaraiDanilo CucchiLuana AbballeZein Mersini BesharatGiuseppina CatanzaroPaola InfanteLucia Di MarcotullioGianluca CanettieriEnrico De SmaeleIsabella ScrepantiFranco LocatelliElisabetta FerrettiPublished in: BMC cancer (2017)
Our results identify a new molecular mechanism involving miR-326 and Arrb1 as regulators of SHH-MB CSCs. Specifically, low levels of Arrb1 and miR-326 trigger and maintain Hh/Gli signaling and self-renewal.