Glioma stem cells activate platelets by plasma-independent thrombin production to promote glioblastoma tumorigenesis.
Anthony R SloanChristine Lee-PoturalskiHarry C HoffmanPeggy L HarrisTheresa E ElderBrian RichardsonAmber Kerstetter-FogleGino CioffiJulia SchroerAnsh DesaiMark CameronJill Barnholtz-SloanJeremy RichEckhard JankowskyAnirban Sen GuptaAndrew E SloanPublished in: Neuro-oncology advances (2022)
Our findings uncover a specific preferential relationship between platelets and GSCs that drive GBM malignancies and identify a therapeutically targetable novel interaction.
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