Src is essential for the endosomal delivery of the FGFR4 signaling complex in hepatocellular carcinoma.

Published in: Journal of translational medicine (2021)

We found that Src is essential for the endosomal delivery of the FGFR4 signaling complex in HCC. Our findings provide a scientific rationale for repurposing Src inhibitors for the treatment of HCCs in which the FGFR4 pathway is activated.

Keyphrases

tyrosine kinase
combination therapy